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-synuclein, which is a principal part of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, which can be an E3 ubiquitin ligase and will cause endoplasmic reticulum (ER) worry, suggest that dysfunction from the intracellular proteinase methods, for instance ubiquitin-proteasome process or lysosomal procedure, which eliminates unwanted poi

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